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Cats aren't immune to emotional highs and lows. Like us, they experience fear, anger, grief, and even depression. And their behavior will show it.
Is your cat more sleepy, jumpy, or withdrawn than usual? Not so interested in eating, playing, cuddling, or grooming? He may be depressed. Illness could be behind it, so your vet should rule this out. But more often it's a traumatic event, such as the loss of a human or animal companion, rehoming, a move, a vacation, or less time with you. Your moods can affect his, too.
Help your kitty chase away the blues with extra love, conversation, playtime, and petting. If that doesn't help, contact your vet or an animal behaviorist.